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More research is needed to determine the optimal duration of preventative therapy but, given the large numbers of patients co-infected with latent tb and hiv, the prophylactic use of isoniazid may have a significant impact on hiv-associated morbidity and mortality.
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The study found that rapid molecular tests for rifampicin and isoniazid resistance resistance in tuberculosis were sensitive and specific, and may be cost-effective when added to culture drug susceptibility testing in the uk.
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