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Concomitant use of amantadine hydrochloride 100 mg 3 times daily and a fixed-combination preparation containing triamterene and hydrochlorothiazide co-triamterzide in a 61-year-old man with parkinsonian syndrome resulted in increased plasma concentrations of amantadine; however, it is not known which component of the combination preparation may have been responsible for the interaction or whether related drugs would produce a similar effect.
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Following vaccination during an influenza a outbreak, symmetrel amantadine hydrochloride prophylaxis should be considered for the 2- to 4-week time period required to develop an antibody response.
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