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Do not change your dose without your doctor s advice; take synthroid at the same time every day.

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In the treatment of well-differentiatedpapillary and follicularthyroid cancerlevothyroxine is used as an adjunct to surgery and radioiodine therapyGenerallyTSH is suppressed to.

Circulating thyroid hormones are greater than 99bound to plasma proteinsincluding thyroxinebinding globulinTBGthyroxine-binding prealbuminTBPAand albuminTBAwhose capacities and affinities vary for each hormoneThe higher affinity of both TBG and TBPA for T 4 partially explains the higher serum levelsslower metabolic clearanceand longer half-life of T 4 compared to T 3Protein-bound thyroid hormones exist in reverse equilibrium with small amounts of free hormoneOnly unbound hormone is metabolically activeMany drugs and physiologic conditions affect the binding of thyroid hormones to serum proteinssee DRUG INTERACTIONS and Drug-Laboratory Test InteractionsThyroid hormones do not readily cross the placental barriersee PRECAUTIONSPregnancy

Get emergency help immediately if any of the following symptoms of overdose occur while taking levothyroxine:

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genetics it is possible that individual genetics may predict responses to synthroid, as well as weight changes.