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The study could not have been done without the help of the study participantstechnical and administrative support and the medical teams and field workers at the local study sites.

The SERPINA1 gene provides instructions for making a protein called alpha-1 antitrypsinwhich is a type of serine protease inhibitorserpinSerpins help control several types of chemical reactions by blockinginhibitingthe activity of certain enzymesAlpha-1 antitrypsin prevents the digestive enzyme trypsin from breaking down proteins until trypsin reaches the intestinesAlpha-1 antitrypsin also inhibits other enzymesincluding a powerful enzyme called neutrophil elastase that is released from white blood cells to fight infection.

AffiliationDepartments of Health Sciences and GeneticsUniversity of LeicesterLeicesterUnited Kingdom.

SAPALDIA study design for the determination of AAT associated genetic variantsa consisting of subjects with abnormally low AAT levels independent of PI S or Z allelessee Materials and Methods

AffiliationDepartment of Epidemiology and BiostatisticsImperial College LondonLondonUnited Kingdom.

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