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In case of severe skinliveror hypersensitivity reactionnevirapine must be discontinued permanently.

Treatment with Viramune should be given by a doctor who has experience in the treatment of HIV infection.

Serum levels of nevirapine can be reduced by concomitant use of the herbal preparation StJohn’s WortHypericum perforatumThis is due to induction of medicinal product metabolism enzymes and/or transport proteins by StJohn’s Wort.

Indicated for treatment of HIV-1 infection in combination with other antiretroviralsalso used for prevention of maternal-fetal HIV transmission in women with no prior antiretroviral treatment.

The dose must be strictly adhered toespecially the 14-days lead-in periodsee section 4.2

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