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Start patients with contraindications to treatment during the early phase of suspected or definite myocardial infarction, patients who appear not to tolerate the full early treatment, and patients in whom the physician wishes to delay therapy for any other reason on metoprolol tartrate tablets, 100 mg twice daily, as soon as their clinical condition allows.

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Safety and effectiveness of TOPROL-XL have not been established in patients.

TOPROL-XL is indicated for the treatment of stablesymptomaticNYHA Class II or IIIheart failure of ischemichypertensiveor cardiomyopathic originIt was studied in patients already receiving ACE inhibitorsdiureticsandin the majority of casesdigitalisIn this populationTOPROL-XL decreased the rate of mortality plus hospitalizationlargely through a reduction in cardiovascular mortality and hospitalizations for heart failure.

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All medicines can have side effectsSometimes they are seriousmost of the time they are notYou may need medical treatment if you get some of the side effects.

Drug interactions may change how your medications work or increase your risk for serious side effectsThis document does not contain all possible drug interactionsKeep a list of all the products you useincluding prescription/nonprescription drugs and herbal productsand share it with your doctor and pharmacistDo not startstopor change the dosage of any medicines without your doctor’s approval.

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pediatrics the pharmacokinetic profile of metoprolol succinate extended-release tablets was studied in 120 pediatric hypertensive patients 6 to 17 years of age receiving doses ranging from 12.