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Financial disclosureDrFava has received research support from AbbottLichtwer Pharma GmbHand Lorexhas received honoraria from BayerCompellisCypressDov PharmaceuticalsJanssenKnollLundbeckand Somersetand has received both research support and honoraria from AspectAstraZenecaBristol-Myers SquibbCephalonEli LillyForestGlaxoSmithKlineJJ PharmaceuticalsNovartisOrganonPfizerPharmaviteRocheSanofi-SynthelaboSolvayand Wyeth-AyerstDrRush has received grant/research support from the National Institute of Mental Healththe Robert Wood Johnson Foundationand the Stanley Foundationhas been a consultant/advisor for Bristol-Myers SquibbCyberonicsEli LillyForestGlaxoSmithKlineOrganonand the Urban Instituteand has participated in speakers bureaus for CyberonicsEli LillyForestand GlaxoSmithKlineDrThase has been a consultant for AstraZenecaBristol-Myers SquibbCephalonCyberonicsEli LillyForestGlaxoSmithKlineJanssenNovartisOrganonPfizerand Wyeth and has participated in speakers bureaus for AstraZenecaEli LillyGlaxoSmithKlineOrganonand WyethDrClayton has received grant support from BayerBoehringer IngelheimEli LillyGlaxoSmithKlineMerckNeuroneticsOrganonPfizerand Pherinhas been a consultant for and participated in advisory boards of BayerBoehringer IngelheimEli LillyGlaxoSmithKlineOrganonPfizerVelaand Wyethand has received honoraria from and participated in speakers bureaus for Eli LillyGlaxoSmithKlineOrganonPfizerand WyethDrStahl has received grant/research support from AbbottAsahiAstraZenecaBristol-Myers SquibbCephalonCypress BioscienceEli LillyGlaxoSmithKlinePfizerPierre Fabreand Wyeth and has received honoraria from and been a consultant for AbbottAsahiAstraZenecaBristol-Myers SquibbCephalonCypress BioscienceEli LillyGlaxoSmithKlineOrganonPfizerPierre FabreSanofi-Synthelaboand WyethDrPradko has been a consultant for GlaxoSmithKline and has participated in speakers/advisory boards for GlaxoSmithKlinePfizerand WyethDrJohnston is retired from and has been a consultant for GlaxoSmithKline.
Postmarketing reportsAltered prothrombin time/INR with/without hemorrhagic/thrombotic complicationsleukocytosislymphadenopathypancytopeniaRef]
EndocrineAlso observed were hyperglycemiahypoglycemiaand syndrome of inappropriate antidiuretic hormone.
Postmarketing reportsCompleted suicidedeliriummanic reactionrestlessnesssuicidal behaviorsuicide attemptRef]
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