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Table 4Incidence of Low Vitamin Values on Two or More Consecutive VisitsNonsupplemented Adult Patients With Normal Baseline ValuesFirs t and Second Year)

Vitamin K absorption may be decreased with XENICALReports of decreased prothrombinincreased INR and unbalanced anticoagulant treatment resulting in change of hemostatic parameters have been reported in patients treated concomitantly with XENICAL and anticoagulantsPatients on chronic stable doses of warfarin or other anticoagulants who are prescribed XENICAL should be monitored closely for changes in coagulation parameterssee CLINICAL PHARMACOLOGY

National Institute of Diabetes and Digestive and Kidney DiseasePrescription Medications for the Treatment of Obesity

XENICALorlistatis a gastrointestinal lipase inhibitor for obesity management that acts by inhibiting the absorption of dietary fats.

XENICAL is contraindicated during pregnancybecause weight loss offers no potential benefit to a pregnant woman and may result in fetal harmA minimum weight gainand no weight lossis currently recommended for all pregnant womenincluding those who are already overweight or obesedue to the obligatory weight gain that occurs in maternal tissues during pregnancyNo embryotoxicity or teratogenicity was seen in animals that received orlistat at doses much higher than the recommended human doseIf this drug is used during pregnancyor if the patient becomes pregnant while taking this drugthe patient should be apprised of the potential hazard of maternal weight loss to the fetus.

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a distinctive feature of orlistat diet pills is that fats neither are splitted nor absorbed in the digestive tract after their oral administration.