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Malaria is a life threatening disease and a major health risk for travellers visiting tropical countries.

Tell your prescriber about all the medicines you takeincluding prescription and non-prescription medicinesvitaminsand herbal supplementsSome medicines may give you a higher chance of having serious side effects from Lariammefloquine

Please seek medical help immediately if you experience serious mental problems while taking LariamLariam should be stopped immediately and replaced with another medicine to prevent malaria.

No pharmacokinetic studies have been performed in patients with renal insufficiency since only a small proportion of the drug is eliminated renallyMefloquine and its main metabolite are not appreciably removed by hemodialysisNo special chemoprophylactic dosage adjustments are indicated for dialysis patients to achieve concentrations in plasma similar to those in healthy persons.

Strains of Pfalciparum with decreased susceptibility to mefloquine can be selected in vitro or in vivoResistance of Pfalciparum to mefloquine has been reported in areas of multi-drug resistance in South East AsiaIncreased incidences of resistance have also been reported in other parts of the world.

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