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Selected laboratory abnormalities of severe or life-threatening intensity reported in patients treated with CRIXIVAN aloneCRIXIVAN in combination with zidovudine or zidovudine plus lamivudinezidovudine aloneor zidovudine plus lamivudine are presented in Table 11.

For optimal absorptionCRIXIVAN should be administered without food but with water 1 hour before or 2 hours after a mealAlternativelyCRIXIVAN may be administered with other liquids such as skim milkjuicecoffeeor teaor with a light meale.gdry toast with jellyjuiceand coffee with skim milk and sugaror corn flakesskim milk and sugarsee CLINICAL PHARMACOLOGYEffect of Food on Oral Absorption and DOSAGE AND ADMINISTRATIONIngestion of CRIXIVAN with a meal high in caloriesfatand protein reduces the absorption of indinavir.

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urogenital system nephrolithiasis urolithiasis, in some cases resulting in renal insufficiency or acute renal failure, pyelonephritis with or without bacteremia see warnings ; interstitial nephritis sometimes with indinavir crystal deposits; in some patients, the interstitial nephritis did not resolve following discontinuation of crixivan; renal insufficiency; renal failure; leukocyturia see precautions , crystalluria; dysuria.