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The occurrence of stupormuscular rigiditysevere agitationand elevated temperature has been reported in some patients receiving the combination of selegiline and meperidineSymptoms usually resolve over days when the combination is discontinuedThis is typical of the interaction of meperidine and MAOIsOther serious reactionsincluding severe agitationhallucinationsand deathhave been reported in patients receiving this combinationsee CONTRAINDICATIONSSevere toxicity has also been reported in patients receiving the combination of tricyclic antidepressants and ELDEPRYL and selective serotonin re-uptake inhibitors and ELDEPRYLSee WARNINGS for detailsOne case of hypertensive crisis has been reported in a patient taking the recommended doses of selegiline and a sympathomimetic medicationephedrine

Patients should be advised of the possible need to reduce levodopa dosage after the initiation of ELDEPRYL therapy.

People with Parkinson’s disease may have a higher risk of skin cancermelanomaTalk to your doctor about this risk and what skin symptoms to watch for.

Death has been reported to occur following the initiation of therapy with non-selective MAO inhibitors shortly after discontinuation of fluoxetineFluoxetine should not be used less than 14 days after discontinuation of selegilineSince fluoxetine has a very long elimination half lifeat least 5 weeks should be allowed after stopping fluoxetine and before starting selegiline.

Use of Eldepryl beyond the recommended dose could lead to non-selectivity and serious adverse effects.

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