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If probalan is given with methotrexate, the dosage of methotrexate should be reduced and serum levels may need to be monitored.

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The good newsThese side effects can often be short-circuited by taking a folic acid supplementFolic acid is the synthetic form of folateOne study found that RA patients on methotrexate who took folic acid supplements lowered the risk of GI problems and mouth sores by 79 percent.

DisclaimerOur goal is to provide you with the most relevant and current informationHoweverbecause drugs affect each person differentlywe cannot guarantee that this information includes all possible side effectsThis information is not a substitute for medical adviceAlways discuss possible side effects with a healthcare provider who knows your medical history.

Live vaccinesWhen used with methotrexatelive vaccines raise your risk of infectionThe vaccine may also not work as wellLive vaccinessuch as FluMistare vaccines that contain small amounts of livebut weakenedviruses

Methotrexate can harm an unborn baby or cause birth defectswhether the mother or father is taking this medicine.

Read the Patient Information Leaflet if available from your pharmacist before you start taking methotrexate and each time you get a refillIf you have any questionsask your doctor or pharmacist.

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selected dmards, including intramuscular gold, cyclosporine, hydroxychloroquine and sulfasalazine together , and doxycycline, given in combination with methotrexate appear to result in increased efficacy compared with methotrexate alone.