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If no reaction occurs after this, 25 mg of naltrexone hydrochloride can be administered to the patient.

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REVIA blocks the effects of opioids by competitive bindingi.eanalogous to competitive inhibition of enzymesat opioid receptorsThis makes the blockade produced potentially surmountablebut overcoming full naltrexone blockade by administration of very high doses of opiates has resulted in excessive symptoms of histamine release in experimental subjects.

The drug is reported to be of greatest use in good prognosis opioid addicts who take the drug as part of a comprehensive occupational rehabilitative programbehavioral contractor other compliance-enhancing protocolREVIAunlike methadone or LAAMlevoalpha-acetyl-methadoldoes not reinforce medication compliance and is expected to have a therapeutic effect only when given under external conditions that support continued use of the medication.

Alcohol-and opioid-dependent patientsincluding those taking REVIAshould be monitored for the development of depression or suicidal thinkingFamilies and caregivers of patients being treated with REVIA should be alerted to the need to monitor patients for the emergence of symptoms of depression or suicidalityand to report such symptoms to the patient’s healthcare provider.

This medication may be sometimes prescribed for other usesask your doctor or pharmacist for more information.

There are no data that demonstrate an unequivocally beneficial effect of REVIA on rates of recidivism among detoxifiedformerly opioid-dependent individuals who self-administer the drugThe failure of the drug in this setting appears to be due to poor medication compliance.

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