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Pump Dose Adjustment and Titration In most patientsit will be necessary to increase the dose gradually over time to maintain effectivenessa sudden requirement for substantial dose escalation typically indicates a catheter complicationi.ecatheter kink or dislodgement

The precise mechanism of action of Lioresal is not fully knownLioresal is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal levelpossibly by hyperpolarization of afferent terminalsalthough actions at supraspinal sites may also occur and contribute to its clinical effectAlthough Lioresal is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acidGABAthere is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effectsIn studies with animalsLioresal has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerancesomnolenceataxiaand respiratory and cardiovascular depressionLioresal is rapidly and extensively absorbed and eliminatedAbsorption may be dose-dependentbeing reduced with increasing dosesLioresal is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.

Store at room temperature away from light and moistureDo not store in the bathroomKeep all medications away from children and pets.

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