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When bystolic is administered with fluoxetine, significant increases in d-nebivolol may be observed ie, an 8-fold increase in auc and a 3-fold increase in c max for d nebivolol .
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Fluoxetine is used to treat major depressive disorderbulimia nervosaan eating disorderobsessive-compulsive disorderpanic disorderand premenstrual dysphoric disorderPMDD
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however, one prospective cohort study conducted by the european network of teratology information services reported an increased risk of cardiovascular malformations in infants born to women n 253 exposed to fluoxetine during the first trimester of pregnancy compared to infants of women n 1,359 who were not exposed to fluoxetine.