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Vinca alkaloidsAlthough not studiedfluconazole may increase the plasma levels of the vinca alkaloidse.gvincristine and vinblastineand lead to neurotoxicitywhich is possibly due to an inhibitory effect on CYP3A4.
Initial dose may be used on the first day to achieve steady state levels more rapidly.
Patients who develop abnormal liver function tests during fluconazole therapy must be monitored closely for the development of more serious hepatic injury.
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