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The side effects of Mestinon are most commonly related to overdosage and generally are of two varietiesmuscarinic and nicotinicAmong those in the former group are nauseavomitingdiarrheaabdominal crampsincreased peristalsisincreased salivationincreased bronchial secretionsmiosis and diaphoresisNicotinic side effects are comprised chiefly of muscle crampsfasciculation and weaknessMuscarinic side effects can usually be counteracted by atropinebut for reasons shown in the preceding section the expedient is not without dangerAs with any compound containing the bromide radicala skin rash may be seen in an occasional patientSuch reactions usually subside promptly upon discontinuance of the medication.
Mestinon is contraindicated in mechanical intestinal or urinary obstructionand particular caution should be used in its administration to patients with bronchial asthmaCare should be observed in the use of atropine for counteracting side effectsas discussed below.
SMA is a genetic neurodegenerative disease that involves impairment of the neuromuscular transmissionSo Mestinonwhich facilitates the nerve signal transmission at the neuromuscular junctionNMJby inhibiting acetylcholine breakdowncould be a potential therapy for SMA.
A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.
Mestinonpyridostigmine bromideis a drug commonly used for treating myasthenia gravisThe drug is currently under investigation for spinal muscular atrophySMA
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if they do occur, the side effects of generic for mestinon are most likely to be minor and temporary.