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What is the mechanism of actionCyclophosphamide belongs to a group of drugs referred to as alkylating drugsCyclophosphamide produces anti-cancer effects by causing a chemical reaction that damages the DNA in a cellThis DNA damage results in cellular death.

Nauseavomitingloss of appetitestomach achediarrheaor darkening of the skin/nails may occurNausea and vomiting can be severeIn some casesdrug therapy may be necessary to prevent or relieve nausea and vomitingChanges in diet such as eating several small meals or limiting activity may help lessen some of these effectsIf these effects persist or worsennotify your doctor or pharmacist promptly.

Renal and Urinaryrenal failurerenal tubular disorderrenal impairmentnephropathy toxichemorrhagic cystitisbladder necrosiscystitis ulcerativebladder contracturehematurianephrogenic diabetes insipidusatypical urinary bladder epithelial cells.

Anaphylactic reactions have been reporteddeath has also been reported in association with this eventPossible cross-sensitivity with other alkylating agents has been reportedSIADHsyndrome of inappropriate ADH secretionhas been reported with the use of cyclophosphamideMalaise and asthenia have been reported as part of the postmarketing experience.

Risk of potentially fatal and irreversible interstitial pulmonary fibrosis if given over prolonged periods.

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