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Although there has been no systematic evaluation of the efficacy of desyrel trazodone hydrochloride beyond six weeks, it is generally recommended that a course of antidepressant drug treatment should be continued for several months.

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Patients with major depressive disorderMDDboth adult and pediatricmay experience worsening of their depression and/or the emergence of suicidal ideation and behaviorsuicidalityor unusual changes in behaviorwhether or not they are taking antidepressant medicationsand this risk may persist until significant remission occursThere has been a long-standing concern that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patientsAntidepressants increased the risk of suicidal thinking and behaviorsuicidalityin short-term studies in children and adolescents with Major Depressive DisorderMDDand other psychiatric disorders.

All pediatric patients being treated with antidepressants for any indication should be observed closely for clinical worseningsuicidalityand unusual changes in behaviorespecially during the initial few months of a course of drug therapyor at times of dose changeseither increases or decreasesSuch observation would generally include at least weekly face-to-face contact with patients or their family members or caregivers during the first 4 weeks of treatmentthen every other week visits for the next 4 weeksthen at 12 weeksand as clinically indicated beyond 12 weeksAdditional contact by telephone may be appropriate between face-to-face visits.

Because the frequency of adverse drug effects is affected by diverse factorsegdrug dosemethod of detectionphysician judgmentdisease under treatmentetca single meaningful estimate of adverse event incidence is difficult to obtainThis problem is illustrated by the variation in adverse event incidence observed and reported from the inpatients and outpatients treated with DesyrelIt is impossible to determine precisely what accounts for the differences observed.

Overdose symptoms may include extreme drowsinessvomitingpenis erection that is painful or prolongedfast or pounding heartbeatseizureblack-out or convulsionsor breathing that slows or stops.

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in humans, desyrel trazodone hydrochloride is well absorbed after oral administration without selective localization in any tissue.