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Subsequent metabolism of the 2-oxoclopidogrel intermediate metabolite results in formation of the active metabolite, a thiol derivative of clopidogrel.
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Gemfibrozil can cause problems when used together with the statin family of cholesterol-reducing medicationsfor example:
Gemfibrozil increases blood levels of repaglinidePrandinin people with diabetesincreasing the likelihood of developing low blood sugarhypoglycemiaThis combination should be avoided.
Gemfibrozil is used for reducing elevated triglyceride levels that are high enough to cause pancreatitisBecause gemfibrozil raises HDL and decreases triglycerides it is prescribed for preventing coronary heart disease in individuals without a history or symptoms of coronary heart disease who have low HDLhigh LDL and high triglyceridesGemfibrozil is prescribed after other therapies have failedand it is not intended for treating patients who only have low HDLGemfibrozil is used together with diet and exercise.
Jay WMarksMDis a board-certified internist and gastroenterologistHe graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
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0 of patients in the clopidogrel group and 21.