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No information is available from controlled clinical studies regarding the use of CELEBREX in patients with advanced renal diseaseThe renal effects of CELEBREX may hasten the progression of renal dysfunction in patients with preexisting renal disease.

The pharmacological activity of CELEBREX in reducing inflammationand possibly fevermay diminish the utility of diagnostic signs in detecting infections.

Harris ClearfieldMDa professor at Drexel University College of Medicine in Philadelphiatells WebMD the findingsdo make me somewhat more confident in prescribingCelebrexto ulcerative colitis patients who are in remissionHe says that it willhoweverbe necessary to monitor patients for potential side-effects of long-term use.

In controlled clinical trialselevated BUN occurred more frequently in patients receiving CELEBREX compared with patients on placeboThis laboratory abnormality was also seen in patients who received comparator NSAIDs in these studiesThe clinical significance of this abnormality has not been established.

For the management of the signs and symptoms of JRA in patients 2 years and oldersee Clinical Studies

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for instance, celebrex, as well as other nsaids, have the greater chance of causing cardiovascular problems such as heart attacks and strokes.