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If you think you, or someone you care for, might have accidentally taken more than the recommended dose of colchicine or intentional overdose is suspected, contact your local hospital, gp or if in england call 111.

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Toxic manifestations associated with colchicine include myelosuppressiondisseminated intravascular coagulationand injury to cells in the renalhepaticcirculatoryand central nervous systemThese most often occur with excessive accumulation or overdosagesee OVERDOSE

Before taking this medicationtell your doctor or pharmacist if you are allergic to itor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.

If you are taking this medication to prevent gout attacks or for pericarditisask your doctor about the dose and schedule you should followCarefully follow your doctor’s directions.

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Published studies demonstrated that colchicine was negative for mutagenicity in the bacterial reverse mutation assayHoweverin vitro chromosomal aberration assays demonstrated the formation of micronuclei following colchicine treatmentBecause published studies demonstrated that colchicine induces aneuploidy through the process of mitotic nondisjunction without structural DNA changescolchicine is not considered clastogenicalthough micronuclei are formed.

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do not take this medicine with any of the following medications -boceprevir -cyclosporine -danazol -gemfibrozil -medicines for fungal infections like itraconazole, ketoconazole, posaconazole, voriconazole -medicines for hiv infection -mifepristone, ru-486 -nefazodone -red yeast rice -some antibiotics like clarithromycin, erythromycin, telithromycin -telaprevir this medicine may also interact with the following medications -alcohol -amiodarone -amlodipine -colchicine -digoxin -diltiazem -dronedarone -fluconazole -grapefruit juice -niacin -ranolazine -verapamil -warfarin.