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Evaluate hematologic status prior to and during treatment with HYDREAProvide supportive care and modify dose or discontinue HYDREA as neededRecovery from myelosuppression is usually rapid when therapy is interrupted.

Hydroxyurea causes severe myelosuppressionTreatment with hydroxyurea should not be initiated if bone marrow function is markedly depressedBone marrow suppression may occurand leukopenia is generally its first and most common manifestationThrombocytopenia and anemia occur less often and are seldom seen without a preceding leukopeniaBone marrow depression is more likely in patients who have previously received radiotherapy or cytotoxic cancer chemotherapeutic agentsuse hydroxyurea cautiously in such patients.

Hydroxyurea may be used as part of a combination therapyThis means you may need to take it with other medications.

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