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In humansDesyrel is well absorbed after oral administration without selective localization in any tissueWhen Desyrel is taken shortly after ingestion of foodthere may be an increase in the amount of drug absorbeda decrease in maximum concentration and a lengthening in the time to maximum concentrationPeak plasma levels occur approximately one hour after dosing when Desyrel is taken on an empty stomach or two hours after dosing when taken with food.

Because the frequency of adverse drug effects is affected by diverse factorsegdrug dosemethod of detectionphysician judgmentdisease under treatmentetca single meaningful estimate of adverse event incidence is difficult to obtainThis problem is illustrated by the variation in adverse event incidence observed and reported from the inpatients and outpatients treated with DesyrelIt is impossible to determine precisely what accounts for the differences observed.

Some young people have thoughts about suicide when first taking an antidepressantYour doctor will need to check your progress at regular visits while you are using trazodoneYour family or other caregivers should also be alert to changes in your mood or symptoms.

Patientstheir familiesand their caregivers should be encouraged to be alert to the emergence of anxietyagitationpanic attacksinsomniairritabilityhostilityaggressivenessimpulsivityakathisiapsychomotor restlessnesshypomaniamaniaother unusual changes in behaviorworsening of depressionand suicidal ideationespecially early during antidepressant treatment and when the dose is adjusted up or downFamilies and caregivers of patients should be advised to observe for the emergence of such symptoms on a day-to-day basissince changes may be abruptSuch symptoms should be reported to the patient’s prescriber or health professionalespecially if they are severeabrupt in onsetor were not part of the patient’s presenting symptomsSymptoms such as these may be associated with an increased risk for suicidal thinking and behavior and indicate a need for very close monitoring and possibly changes in the medication.

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