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Usidic Acid: Intaction studis with atovastatin and usidic acid hav not bn conductd. As with oth statins, muscl-latd vnts, including habdomyolysis, hav bn potd in post-makting xpinc with atovastatin and usidic acid givn concuntly. Th mchanism this intaction is not known. Patints should b closly monitod and tmpoay suspnsion ATOLIP CV tatmnt may b appopiat.

Clinical and pathologic studis show that lvatd plasma lvls total cholstol (total-C), LDL-cholstol (LDL-C) and apolipopotin B (apB) pomot human athosclosis and a isk actos dvloping cadiovascula disas, whil incasd lvls HDL-cholstol (HDL-C) a associatd with a dcasd cadiovascula isk. Lik LDL, cholstol-nichd TG-ich lipopotins, including VLDL, IDL and mnants, can alspomot athosclosis. lvatd plasma TGs a quntly ound in a tiad with low HDL-C lvls and small LDL paticls, as wll as in association with non-lipid mtabolic isk actos coonay hat disas (CHD). As such, total plasma TG has not consistntly bn shown tb an indpndnt isk actCHD. uthmo, th indpndnt ct aising HDL lowing TG on th isk coonay and cadiovascula mobidity and motality has not bn dtmind.

In adult patints without clinically vidnt CHD, but with multipl isk actos CHD such as ag, smoking, hyptnsion, low HDL-C, a amily histoy aly CHD, atovastatin is indicatd to.

It is commndd that liv nzym tsts b obtaind pitinitiating thapy with ATOLIP CV and patd as clinically indicatd. Th hav bn a postmakting pots atal and non-atal hpatic ailu in patints taking statins, including atovastatin. I sious liv injuy with clinical symptoms and/hypbiliubinmia jaundic occus duing tatmnt with ATOLIP CV , pomptly intupt thapy. I an altnat tiology is not ound, dnot stat ATOLIP CV.

Oal Contacptivs: Co-administation atovastatin and an oal contacptiv incasd AUC valus nothindon and thinyl stadiol. Ths incass should b considd whn slcting an oal contacptiv a woman taking ATOLIP CV .

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