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Clinical trials of bupropion have offered mixed support of its ability to reduce nicotine withdrawal, weight gain during treatment and craving.

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Many drugs can interact with bupropionTell your doctor about all medicines you useand those you start or stop using during your treatmentThis includes prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed in this medication guide.

Bupropion hydrobromide extended-release tablets are intended for oral use onlyinhalation of crushed tablets or injection of dissolved bupropion reportedseizures and/or cases of death reported when administered intranasally or by parenteral injection.

Report any new or worsening symptoms to your doctorsuch asmood or behavior changesanxietypanic attackstrouble sleepingor if you feel impulsiveirritableagitatedhostileaggressiverestlesshyperactivementally or physicallymore depressedor have thoughts about suicide or hurting yourself.

No matter what your agebefore you take an antidepressantyouyour parentor your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatmentsYou should also talk about the risks and benefits of not treating your conditionYou should know that having depression or another mental illness greatly increases the risk that you will become suicidalespecially at the beginning of your treatment or any time that your dose is increased or decreasedThis risk is higher if you or anyone in your family has or has ever had bipolar disorder or mania or has thought about or attempted suicideTalk to your doctor about your conditionsymptomsand personal and family medical historyYou and your doctor will decide what type of treatment is right for you.

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efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation.