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The thiazides may decrease serum PBI levels without signs of thyroid disturbance.

MAXZIDEtriamterene and hydrochlorothiazideshould not be used in the presence of elevated serum potassium levelsgreater than or equal to 5.5 mEq/literIf hyperkalemia developsthis drug should be discontinued and a thiazide alone should be substituted.

MAXZIDEtriamterene and hydrochlorothiazideis indicated for the treatment of hypertension or edema in patients who develop hypokalemia on hydrochlorothiazide aloneMAXZIDE is also indicated for those patients who require a thiazide diuretic and in whom the development of hypokalemia cannot be riskede.gpatients on concomitant digitalis preparationsor with a history of cardiac arrhythmiasetc

Side effects observed in association with the use of MAXZIDEother combination products containing triamterene/hydrochlorothiazideand products containing triamterene or hydrochlorothiazide include the following:

Fluid and electrolyte imbalances are the most important concernExcessive doses of the triamterene component may elicit hyperkalemiadehydrationnauseavomiting and weakness and possibly hypotensionOverdosing with hydrochlorothiazide has been associated with hypokalemiahypochloremiahyponatremiadehydrationlethargymay progress to comaand gastrointestinal irritationTreatment is symptomatic and supportiveTherapy with MAXZIDEtriamterene and hydrochlorothiazideshould be discontinuedInduce emesis or institute gastric lavageMonitor serum electrolyte levels and fluid balance.

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the amount of triamterene added to 50 mg of hydrochlorothiazide in triamterene and hydrochlorothiazide tablets was determined from steady-state dose-response evaluations in which various doses of liquid preparations of triamterene were administered to hypertensive persons who developed hypokalemia with hydrochlorothiazide 50 mg given once daily .